Calculate Creatinine Clearance
Understanding Creatinine Clearance
Creatinine clearance is a crucial measure of kidney function that helps healthcare providers assess how well the kidneys are filtering waste from the blood.
Normal Values
Normal creatinine clearance values typically range from 90-140 mL/min in males and 80-125 mL/min in females.
When to Check
Regular monitoring is recommended for patients with kidney disease, diabetes, hypertension, or those taking nephrotoxic medications.
Clinical Applications
Diagnosis
Early detection of kidney dysfunction and disease progression monitoring
Medication Dosing
Adjustment of medication doses for drugs cleared by the kidneys
Risk Assessment
Evaluation of cardiovascular and mortality risk in chronic kidney disease
Latest Research Insights
Accuracy in Elderly Patients
Recent studies suggest that the Cockcroft-Gault equation may need adjustment factors for elderly patients over 75 years.
Alternative Markers
Cystatin C is emerging as a complementary marker to creatinine for more accurate GFR estimation.
Impact of Muscle Mass
New research highlights the importance of considering muscle mass variations in creatinine clearance calculations.
Best Practices
Timing of Measurement
Collect serum samples in the morning when creatinine levels are most stable
Patient Preparation
Avoid high-protein meals and excessive exercise 24 hours before testing
Regular Monitoring
Schedule follow-up tests at consistent intervals for accurate trending
This calculator provides estimates based on the Cockcroft-Gault equation. Results should be interpreted by a healthcare professional in conjunction with clinical findings and laboratory data.